According to the U.S. regulations, any medical institution that wishes to be involved in any clinical study funded by the U.S. federal government or any U.S. governmental agencies (e.g. the U.S. National Institutes of Health (NIH)) is required to engage institutional review boards/research ethics committees (IRBs/RECs) registered with the U.S. Office for Human Research Protections (OHRP) for review and oversight of its clinical studies.

To facilitate collaboration in international clinical research, MUST/UH IRB has registered with the OHRP.  Additionally, each of MUST and UH has filed a Federalwide Assurance (FWA) with the OHRP to acknowledge its reliance on MUST/UH IRB on ethics and scientific oversight of clinical studies.